Comparison of regional metagenes and DNA copy number changes. A) Frequency plot of DNA copy number changes from 43 ER+ breast tumour CGH profiles . B) Corresponding map of regional metagenes from matching gene expression data. C) Regional metagenes from the merged dataset of 793 tumours. In B) and C) the height and direction of the plotted peaks indicate the correlation of the RMGs to the proliferation metagene from the corresponding datasets.