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Table 1 Positive and negative feedback loops of the three regulators of sporulation*.

From: Prediction of quantitative phenotypes based on genetic networks: a case study in yeast sporulation

Regulator

Function

Feedback loops

Ime1

P

i.

Ime1-> Ime1;

  

ii.

Ime1->Ndt80-> Ime1;

  

iii.

Ime1->Ime2->Ndt80-> Ime1.

Ime2

P

i.

Ime2-> Ime2;

  

ii.

Ime2->Ndt80-> Ime2;

  

iii.

Ime2--|Sum1--|Ndt80-> Ime2;

  

iv.

Ime2->Ndt80->Clb1->Cdc28-> Ime2.

Ndt80

P

i.

Ndt80-> Ndt80;

  

ii.

Ndt80->Ime2-> Ndt80;

  

iii.

Ndt80-> Ime2--|Sum1--|Ndt80;

  

iv.

Ndt80->Ime1-> Ndt80;

  

v.

Ndt80->Clb1->Cdc28->Ime2-> Ndt80.

Ime1

N

i.

Ime1-> Ime2/Rim4--|Ime1;

  

ii.

Ime1->Ndt80->Clb1-> Cln2/Cdc28--|Ime1.

  1. * "-> " means the left node activates the right node and "--|" means the left node represses the right node. "P" and "N" represent that the functions of the feedback loops are positive and negative regulation, respectively.
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BMC Systems Biology

ISSN: 1752-0509

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