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Table 2 Effects of removing positive feedback loops.

From: Prediction of quantitative phenotypes based on genetic networks: a case study in yeast sporulation

Perturbation

a*

Ime1 auto-regulation

1.11

Ime1-> Ndt80

1.04

Ndt80-> Ime1

1.14

Ime1-> Ime2

1.00

Ime2-> Ndt80

1.08

Ime2 auto-regulation

1.00

Ndt80-> Ime2

1.00

Ime2--|Sum1

1.59

Sum1--|Ndt80

0.98

Ndt80-> Clb1

0.99

Clb1-> Cdc28

0.97

Cdc28-> Ime2

1.00

Ndt80 auto-regulation

1.01

  1. *a represents the effect of disrupting the edge to the completion of sporulation (see definition of a in the text).