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Table 1 Modeling two mechanisms of microRNA action in the simplest linear model

From: Dynamical modeling of microRNA action on the protein translation process

Observable value Initiation(k1) Step after initiation, cap-independent(k2) Elongation (k3)
Wild-type cap
Steady-state rate decreases decreases no change
Relaxation time increases slightly increases slightly no change
A-cap
Steady-state rate decreases no change no change
Relaxation time no change increases drastically no change
  1. MicroRNA action effect is described for the protein synthesis steady rate and the relaxation time. It is assumed that the ribosome assembly+elongation step in protein translation, described by the k3 rate constant, is not rate limiting.