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Table 1 Modeling two mechanisms of microRNA action in the simplest linear model

From: Dynamical modeling of microRNA action on the protein translation process

Observable value

Initiation(k1)

Step after initiation, cap-independent(k2)

Elongation (k3)

Wild-type cap

Steady-state rate

decreases

decreases

no change

Relaxation time

increases slightly

increases slightly

no change

A-cap

Steady-state rate

decreases

no change

no change

Relaxation time

no change

increases drastically

no change

  1. MicroRNA action effect is described for the protein synthesis steady rate and the relaxation time. It is assumed that the ribosome assembly+elongation step in protein translation, described by the k3 rate constant, is not rate limiting.