TY - JOUR AU - Ptitsyn, Andrey AU - Schlater, Amber AU - Kanatous, Shane PY - 2010 DA - 2010/09/29 TI - Transformation of metabolism with age and lifestyle in Antarctic seals: a case study of systems biology approach to cross-species microarray experiment JO - BMC Systems Biology SP - 133 VL - 4 IS - 1 AB - The metabolic transformation that changes Weddell seal pups born on land into aquatic animals is not only interesting for the study of general biology, but it also provides a model for the acquired and congenital muscle disorders which are associated with oxygen metabolism in skeletal muscle. However, the analysis of gene expression in seals is hampered by the lack of specific microarrays and the very limited annotation of known Weddell seal (Leptonychotes weddellii) genes. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-4-133 DO - 10.1186/1752-0509-4-133 ID - Ptitsyn2010 ER -