BMC Systems Biology

Table 5 The algorithm for the automated calculation of reaction rates (column "rate") and time derivatives for all the isotopomers (shown in left column) of accoa (d_accoa /dt) exemplified for the reaction of efflux of accoa (accoa →).

From: Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis

reaction	rate	d_accoa /dt
00 →	u₀₀= v₀C₀₀/C_accoa	D₀₀= u₀₀₀+u₁₀₀-u₀₀
01 →	u₀₁= v₀C₀₁/C_accoa	D₀₁= u₁₀₁+u₀₀₁-u₀₁
10 →	u₁₀= v₀C₁₀/C_accoa	D₁₀= u₁₁₀+u₀₁₀-u₁₀
11 →	u₁₁= v₀C₁₁/C_accoa	D₁₁= u₁₁₁+u₀₁₁-u₁₁

The pdh reaction (pyr → accoa) shown in Table 4 was already taken into account.

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