Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks

Table 4 Significant biological pathways represented in the set of intersection genes between regions.

Region comparison	Pathways	p value (FDR = 0.05)
EC-HIP	NF-AT signaling in Cardiac Hypertrophy	6.711e-7
	Role of heterochromatin protein 1 (HP1) family in transcriptional silencing	3.309e-6
	NGF activation of NF-kB	9.559e-6
EC-MTG	Cytoskeleton remodelling Neurofilaments	3.564e-8
	Oxidative phosphorylation	1.314e-6
	Development-A2B receptor: action via G-protein alpha s	2.328e-5
EC-PCC	Role of heterochromatin protein 1 (HP1) family in transcriptional silencing	5.846e-7
	Cytoskeleton remodelling-TGF, WNT and cytoskeletal remodelling	7.951e-7
	Chemokines and adhesion	5.369e-6
HIP-MTG	Oxidative phosphorylation	1.615e-24
	Ubiquinone metabolism	2.971e-12
	Clathrin-coated vesicle cycle	3.490e-8
HIP-PCC	Oxidative phosphorylation	6.858e-13
	TGF, WNT and cytoskeletal remodelling	1.037e-7
	Role of 14-3-3 proteins in cell cycle regulation	2.839e-7
PCC-MTG	Oxidative phosphorylation	1.003e-32
	Ubiquinone metabolism	3.485e-16
	Clathrin-coated vesicle cycle	1.789e-8

Identification of differentially expressed (DE) genes was carried out by comparing AD affected and unaffected samples within a region. The intersection of the DE genes between two regions was extracted and significant pathways identified (See Table 2, column 2).

ISSN: 1752-0509