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Table 4 Significant biological pathways represented in the set of intersection genes between regions.

From: Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks

Region comparison Pathways p value (FDR = 0.05)
EC-HIP NF-AT signaling in Cardiac Hypertrophy 6.711e-7
  Role of heterochromatin protein 1 (HP1) family in transcriptional silencing 3.309e-6
  NGF activation of NF-kB 9.559e-6
EC-MTG Cytoskeleton remodelling Neurofilaments 3.564e-8
  Oxidative phosphorylation 1.314e-6
  Development-A2B receptor: action via G-protein alpha s 2.328e-5
EC-PCC Role of heterochromatin protein 1 (HP1) family in transcriptional silencing 5.846e-7
  Cytoskeleton remodelling-TGF, WNT and cytoskeletal remodelling 7.951e-7
  Chemokines and adhesion 5.369e-6
HIP-MTG Oxidative phosphorylation 1.615e-24
  Ubiquinone metabolism 2.971e-12
  Clathrin-coated vesicle cycle 3.490e-8
HIP-PCC Oxidative phosphorylation 6.858e-13
  TGF, WNT and cytoskeletal remodelling 1.037e-7
  Role of 14-3-3 proteins in cell cycle regulation 2.839e-7
PCC-MTG Oxidative phosphorylation 1.003e-32
  Ubiquinone metabolism 3.485e-16
  Clathrin-coated vesicle cycle 1.789e-8
  1. Identification of differentially expressed (DE) genes was carried out by comparing AD affected and unaffected samples within a region. The intersection of the DE genes between two regions was extracted and significant pathways identified (See Table 2, column 2).
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BMC Systems Biology

ISSN: 1752-0509

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