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Table 5 Significant biological pathways in the set of differentially expressed genes between regions.

From: Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks

Region comparison (# DE genes) Pathways p value (FDR = 0.05)
EC-HIP (1349) Ossification and bone remodelling 6.395e-3
  Cell cycle G2-M 8.544e-3
  Cardiac development FGF-ErbB signalling 9.847e-3
  Cell cycle-Mitosis 1.159e-2
EC-MTG (567) Development 5.836e-5
  Transport-RAB3 regulation pathway 1.695e-4
EC-PCC (1685) Role of 14-3-3 proteins in cell cycle regulation 1.188e-5
  Parkin disorder under Parkinson disease 1.474e-5
  TGF, WNT and cytoskeletal remodelling 2.738e-5
HIP-MTG (403) Immune response-T cell receptor signalling 1.947e-6
  Immune response-Fc epsilon RI pathway 3.021e-6
  Dopamine D2 receptor transactivation of PDGFR in CNS 3.335e-6
HIP-PCC (259) Immune response-Function of MEF2 in T lymphocytes 5.157e-8
  Immune response-CCR3 signalling in eosinophils 1.593e-6
  Immune response-Fc epsilon RI pathway 1.853e-6
PCC-MTG (210) none at FDR = 0.05 -
  1. Identification of differential expression was carried out across two brain regions by directly comparing the expression profiles of the two regions. The biological pathways of this set of differentially expressed genes between the regions was investigated and shown here.