Figure 2

Snapshot of the DC signaling pathway map. This map was created using CellDesigner ver.4.0.1, ver.4.0.α, and ver.4.1β http://celldesigner.org/. The main symbols used may slightly differ from those implemented by CellDesigner ver.4.0.1 and ver.4.0.α, as indicated. Interactions are color-coded: black filled arrows, stimulatory reactions; red bar-headed lines, inhibitory reactions; black dashed and double-dotted lines, transcriptional activation reactions (instead of transcription reactions); pink round-headed lines, catalysis reactions; black filled arrows with a bar, transport reactions. The presence of a question mark signifies that, whether the reactions are direct or indirect, is unknown. Translation reactions are represented by dashed and single-dotted lines. Modification states of proteins, i.e. phosphorylation and ubiquitination, are symbolized by P and Ub, respectively. Entities that are bordered with a dotted frame are considered in an active state. The following cellular compartments are illustrated on the diagram, as indicated: cytoplasm, endosome, mitochondria, and nucleus. The color-coding of entities was put together by us: pathogens and PAMPs in turquoise, TLRs in yellow, RLRs in purple, CLRs in pink, NLRs in orange, adaptors in grey, transcription factors in light blue, kinases in light green, and negative regulators in red. The map can be more easily viewed on the web at http://tsb.mssm.edu/pathwayPublisher/DC_pathway/DC_pathway_index.html.