Figure 4

Negative regulations of PRR responses. (a) Negative regulation of TLR3-, RIG-I-, and MDA5-induced pathways by A20. (b) Negative regulation of RIG-I- and TLR3-induced pathways by SIKE. (c) Negative regulation of TLR3- and RIG-I-induced pathways by PIN1. (d) Negative regulation of MDA5 and RIG-I signaling by both RNF125 and NLRX1. (e) Negative regulation of JAK/STAT signaling by SOCS proteins, and of TLR4 signaling by SOCS1. In this diagram, transcriptional activation reactions were represented by black dashed and double-dotted lines, and protein phosphorylation was signified by P.