Figure 1

Discovery of a P2P-R-associated transcription network in fat cells. The top 1000 gene transcripts whose expression covaries with P2P-R in fat cells derived from the BXH/BHX rat recombinant inbred genetic reference panel were exported from GeneNetwork to the WebGestalt gene ontology analysis system to determine with which functional gene sets P2P-R may be associated. In an excerpt of that report, the data shown document that P2P-R is significantly co-expressed with a set of at least 67 transcription-associated gene products with p = 2.81e-4. Review of the 1000 top covariants with P2P-R using the "Trait Data and Analysis Form - IDs" function of GeneNetwork revealed some required revisions of the WebGestalt data and the addition of a few transcription-associated genes to give a total of 75 transcription genes whose expression co-varies (see Additional file 1).