Figure 3

Discovery of a P2P-R-associated transcription network in eye tissue. The top 1000 gene transcripts whose expression co-varies with P2PR in the eye tissue derived from the BXD mouse recombinant inbred genetic reference panel was exported from GeneNetwork to the WebGestalt gene ontology analysis system to determine with which functional gene sets P2P-R may be associated. In an excerpt of that report, the date shown documents that P2P-R is significantly co-expressed with a set of at least 116 transcription-associated gene products with p = 1.55e-5. This set of co-expressed gene transcripts had correlation coefficients of ≥ 0.65. Review of the 1000 top covariants with P2P-R using the "Trait Data and Analysis Form - IDs" function of GeneNetwork revealed some required revisions of the WebGestalt data and the addition of a few transcription-associated genes to give a total of 135 transcription genes whose expression co-varies (see Additional file 2).