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Figure 1 | BMC Systems Biology

Figure 1

From: A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1

Figure 1

Creation of draft mammalian reconstructions. a) A schematic figure showing the two approaches used to generate draft mammalian reconstructions using Recon 1. Approach A removes all gene-associated reactions from Recon 1 without a homologous gene in the reconstructed animal, while keeping all non-gene-associated reactions. Approach B removes all gene-associated reactions from Recon 1 without a homologous gene in the reconstructed as well as non-gene-associated reactions (excluding transporters and demand reactions). GAR - gene-associated-reactions; nGAR - non-gene-associated reaction; transp/dem - transporters and demand reactions. b) Ratio of reactions (black bar) and genes (gray bar) that were successfully mapped from Recon 1 to the indicated mammalian draft reconstruction. c) A phylogenetic tree based on all transcripts of protein domain sequences from the SuperFamily database [64] for all reconstructed mammals. d) A phylogenetic tree based on flux variability analysis (FVA) of all reactions in all mammals reconstructed via approach A. e) A phylogenetic tree based on flux variability analysis (FVA) of all reactions in all mammals reconstructed via approach B.

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