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Figure 2 | BMC Systems Biology

Figure 2

From: A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1

Figure 2

Results from comparison of the flux variability analysis (FVA) for a LPL knockout model with a wild type model. Results from comparison of the flux variability analysis (FVA) for a LPL knockout model with a wild type model. a) A part of triacylglycerol metabolism is shown. Reactions with increased flux capacity in the knockout model are shown in red and reactions with decreased flux capacity are shown in green. b) The distribution of fluxes in FVA of a wild type model (dark gray) compared to knockout model (black) indicates increased flux through the diacylglycerol acetyltransferase (DGAT) and monoacylglycerol acetyltransferase (MOGAT). These results suggest that hypertriglyceridemia can result from knockout of the LPL gene. Reactions: AGPAT1 - 1-acylglycerol-3-phosphate O-acyltransferase 1; DGAT - diacylglycerol acyltransferase; GPAM - glycerol-3-phosphate acyltransferase; LPS - lipoprotein lipase LPS2 - lipoprotein lipase 2; LPS3 - lipase; MOGAT - monoacylglycerol acyltransferase; PPAP - phosphatidic acid phosphatase. Metabolites: a-lysophosphatidic acid; DAG - diacylglycerol (Homo sapiens); G - glycerol; G3p - Glycerol 3-phosphate; MAG - monoacylglycerol 2; PA - phosphatidic acid; R - R groups (total); TAG - triacylglycerol.

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