Sensitivity analysis using local and global-local methods on the thermodynamic model of Fakhouri et al., scheme 2. A) Local sensitivity analysis highlights great differences among parameters. Model parameters are shown on the horizontal axis and local sensitivity coefficients (scaled from 0.0 to 1.0) are shown on the vertical axis. Larger values indicate that the model output changes greatly when this parameter is varied. B) Global-local analysis reveals differences in relative sensitivities compared to local analysis. The global-local sensitivity contribution (also scaled from 0.0 to 1.0) is plotted on the vertical axis. In the global-local analysis, quenching parameters (Q) are generally more sensitive than repressor scaling factors (R), which in turn are more sensitive than cooperativity parameters (C).