Figure 4

Sensitivity analysis using the HDMR global sensitivity method on the thermodynamic model of Fakhouri et al., scheme 2. Shown are first-, second- and the sum of first- and second-order sensitivity indices, which represent the amount of variation in the model output with respect to each parameter individually (light gray bars), each pair of parameters (dark gray bars), and the sum of these two variations (black bars), scaled from 0.0 to 1.0. General sensitivity trends are similar to those observed in Figure 2, although second-order sensitivities are largest for R and C1, implying that they affect the model output through pair-wise interactions with other parameters. Over 95% of the variation in model output was found using only first- and second- order sensitivities (data not shown); therefore the sum of first- and second-order sensitivities shown here approximates the total sensitivity of each parameter.