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Table 1 Mathematical model parameters

From: Mathematical modeling of the dynamic storage of iron in ferritin

Parameter Value Unit Description/comment
General    
Fe pack 50 atom packages-1 Number of atoms in an iron package (Arbitrary)
Fn max 4500 Atom Maximum iron storage capacity in a ferritin protein cage [43]
F n m a x e f f 2500 Atom Maximum measured iron storage capacity for a ferritin
N 50 packages Maximum number of iron atoms packages that a ferritin protein cage can store Fn max /Fe pack
Kinetic constants    
k aso 1.6955 × 1015 pmol-packages-1 hr-1 cell-1 Association constant [15]
k dis 8.25192 × 107 hr-1 Dissociation constant, calculated from k App [46]
k cat 7.776 × 106 hr-1 Catalytic constant [46]
k d 4.33 × 10-2 hr-1 Proteolytic degradation constant [26]
k ˜ l o s s 2.56 × 107 hr-1 Iron release constant: base value (see Figure 8 and text)
Initial conditions    
Fn total 5.52 × 10-7 pmol-ferritin cell-1 Total ferritin in a cell t [15]
Fe 2.7880 × 10-5 pmol-packages cell-1 Initial intracellular iron concentration t = 0 [15]
Fn i 0 pmol-ferritin cell-1 i ≠ 0
Fn 0 nFn total pmol-ferritin cell-1 All ferritin protein cages are empty at t = 0
C F n i F e 0 pmol-ferritin cell-1 There is no intermediary complex at t = 0