In vivo and in vitro transcriptional gene network views. Both gene networks were built using common genes regulated by TNT in vivo and in vitro. The in vivo gene network (A) was constructed using 200 arrays from rat liver tissues treated with one of 5 compounds TNT, 2,4-DNT, 2,6-DNT, 2A-DNT and 4A-DNT or vehicle controls. The in vitro gene network (B) was modeled using 531 arrays resulted from liver primary cultured cells treated by one of 105 compounds with relative controls. The Context Likelihood of Relatedness (CLR) algorithm was employed to build both gene networks. Yellow highlighted genes are transcription factors. (C) Number of connections of transcription factors in vivo and in vitro gene networks. The number of connections of transcription factors in vivo and in vitro gene networks exhibited in Fig. 6A, B was counted.