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Table 2 Commonly regulated canonical pathways based on in vivo, in vitro and common gene lists regulated by TNT

From: In vitro gene regulatory networks predict in vivo function of liver

Pathway -Log(P-value) in vivo -Log(P-value) in vitro -Log(P-value) in vivo and in vitro
Metabolism of Xenobiotics by Cytochrome P450 7.26 4.77 5.82
NRF2-mediated Oxidative Stress Response 6.17 6.05 5.31
LPS/IL-1 Mediated Inhibition of RXR Function 5.66 6.29 3.48
Glutathione Metabolism 8.31 3.33 3.14
Xenobiotic Metabolism Signaling 5.05 5.14 4.4
Pentose and Glucuronate Interconversions 4.63 3.67 4.37
Aryl Hydrocarbon Receptor Signaling 3.82 3.84 3.93
PXR/RXR Activation 3.28 4.34 1.84
Pyruvate Metabolism 4.54 2.15 1.25
Galactose Metabolism 4.11 1.44 1.73
Fructose and Mannose Metabolism 4.19 1.33 1.65
Retinol Metabolism 1.98 1.97 2.59
Biosynthesis of Steroids 1.83 1.56 2.28
Fatty Acid Metabolism 2.3 1.87 1.48
Starch and Sucrose Metabolism 1.11 1.48 2.24
Androgen and Estrogen Metabolism 1.31 1.34 1.74