Functional centrality of low-EV signaling genes. A) Numbers of protein-protein interactions within each signaling hierarchy. B) Plot of average number of interactions of the RS and RS2 level genes depending on their EV. RS and RS2 level genes were arranged in the order of increasing EV and binned into 20 bins. C) Boxplots of numbers of protein-protein interactions of RS and RS2 level genes with high (>0.9) and low (<0.1) EV genes. D) Boxplots of RS and RS2 level genes with Class I and Class II promoter architecture. Y-axes in C and D are on a log scale. P-values show p-values of difference calculated by Wilcoxon test.