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Figure 8 | BMC Systems Biology

Figure 8

From: Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model

Figure 8

Model extension to include integrin activation and phosphorylation in response to mechanical stress. Reactions for stress-induced integrin activation and subsequent phosphorylation by PKA were identified from recent protein interaction data http://www.pathwaycommons.org/pc/. Shown are predicted dynamics during a transient mechanical stress stimulus for Gsα (which is stimulated by the stress input), cAMP, and integrin phosphorylation (Itgbp) by PKA. The mechanisms for this additional pathway are schematized in Additional File 7, Figure S6.

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