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Table 3 GAD disease phenotype testing

From: A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder

GAD Disease Phenotype P-Value Genes (Entrez Gene ID) Fold Enrichment FDR
AGING 2.66E-06 3569, 3558, 7040, 7422, 7157, 3586, 3458, 3576, 5291, 1277, 7124, 367, 6464, 154, 4.92 0.002%
IMMUNE 8.48E-06 3569, 2784, 3265, 6548, 1392, 6774, 3588, 2796, 3570, 2099, 2778, 1843, 6352, 3561, 1956, 367, 3558, 7040, 3572, 7422, 3586, 7157, 3577, 1385, 1906, 3579, 115, 3932, 3560, 3458, 3576, 2782, 1051, 2908, 1277, 7124, 3559, 1128, 116, 154, 1.87 0.006%
CANCER 3.28E-05 3569, 1499, 5997, 2784, 3265, 2796, 1869, 2099, 2778, 6352, 5781, 7032, 5291, 1956, 2932, 367, 6464, 4609, 5290, 3558, 7040, 7422, 1316, 3586, 7157, 5970, 3577, 3579, 1906, 3560, 3458, 3576, 4193, 4088, 2908, 1277, 7124, 154, 1.83 0.025%
INFECTION 9.03E-05 3569, 3558, 7422, 7040, 3586, 7157, 3577, 3579, 3560, 3716, 6772, 3458, 6776, 3576, 2099, 6352, 5781, 4088, 1956, 7124, 3559, 154, 2.46 0.068%
PHARMACOGENOMIC* 3.08E-04 5290, 3569, 7422, 7040, 3586, 7157, 5997, 2784, 1385, 409, 3265, 6774, 3458, 3576, 4193, 2099, 2908, 1956, 1812, 7124, 2932, 154, 2.26 0.230%
PSYCH* 1.64E-03 3569, 5997, 2784, 887, 3265, 1392, 2099, 2778, 1812, 2932, 367, 6571, 3558, 7422, 3586, 7157, 409, 1385, 115, 3560, 4929, 5914, 2908, 7124, 1128, 154, 116, 1.79 1.226%
CHEMDEPENDENCY* 3.08E-03 3576, 2099, 3586, 2908, 1277, 7124, 1812, 2932, 887, 409, 1128, 6571, 2.76 2.284%
METABOLIC 3.70E-03 3569, 860, 5997, 2784, 887, 1392, 2796, 3570, 6654, 2099, 2778, 6352, 5291, 1956, 367, 2932, 6464, 3572, 7040, 7422, 2798, 1316, 3586, 7157, 1906, 3458, 2353, 3576, 4088, 2908, 1277, 7124, 154, 116, 1.54 2.739%
  1. In addition to GeneGo and ConceptGen hypothesis testing, the network model was tested for related disease phenotypes via the Genetic Association Database (GAD). The network is consistent with pharmacogenomic, psychiatric, and chemical dependency phenotypes, as well as phenotypes that are traditionally considered medical.
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BMC Systems Biology

ISSN: 1752-0509

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