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Table 5 Function of target genes of 9 miRNAs.

From: Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma

Gene Ontology (GO) category or pathway Enrichment P-values
  mir-15b mir-15a mir-16 mir-25 mir-106a mir-93 mir-106b mir-92 mir-323
Glioma   1.9E-02        
Regulation of neurotransmitter levels   1.3E-02 1.1E-02       
Neurotransmitter transport 6.8E-03 1.5E-02 3.3E-02 3.9E-02      
Long-term potentiation 4.2E-03 3.7E-05 2.4E-03 3.1E-02   1.4E-02 5.3E-03   
Synaptic transmission 2.4E-04 4.0E-04 5.3E-04 3.0E-06   4.4E-02   1.6E-03  
Neurotransmitter secretion   1.7E-02 1.0E-02 2.9E-02      
Nervous system development 3.2E-02 1.3E-02 5.5E-03     2.7E-02   
Central nervous system development    2.5E-02       
Transmission of nerve impulse 2.3E-04 9.6E-04 4.8E-04 1.8E-06     6.0E-04  
Regulation of synaptic plasticity     4.6E-02      
Synaptic vesicle transport   2.8E-02       3.1E-02  
Regulation of synapse structure and activity     4.6E-02      
Neurological system process 7.1E-03 4.3E-03 5.1E-03 1.5E-04     3.1E-03  
Learning and/or memory 3.7E-02         
Learning 4.0E-02         
Neurofilament     2.1E-02      
Synaptic vesicle 1.1E-02   8.0E-03 2.7E-02      
Synaptosome         1.4E-02  
Synaptic vesicle membrane     3.4E-02      
Neuron projection    4.5E-02       
Synapse part     4.7E-05 1.5E-02 2.5E-03 1.6E-02 1.2E-02  
Synapse 4.9E-03 1.5E-02 2.1E-02 1.1E-07 6.2E-03 8.4E-04 5.3E-03 2.3E-04  
Axon guidance       2.1E-02    
Antigen processing and presentation          4.0E-02
Ras protein signal transduction      1.9E-02   2.3E-02   
Calcium ion transport 1.8E-03 3.6E-04 7.8E-03     4.2E-02   
Calcium signaling pathway 2.7E-04 7.5E-06 1.7E-03 1.7E-02   2.0E-04 2.2E-05   
Cell communication 1.9E-02 2.2E-02 5.6E-03 2.3E-03   1.8E-02 2.6E-02 2.5E-02  
Cell-cell signaling 1.4E-03 8.1E-04 9.5E-04 4.2E-06     7.0E-03  
Wnt signaling pathway   4.0E-02     2.9E-03 7.6E-03   
MAPK signaling pathway   1.5E-02 8.4E-03    3.8E-02 2.6E-02   
GnRH signaling pathway 1.0E-02 8.7E-05 6.6E-03       
ErbB signaling pathway   2.2E-02 3.0E-02       
B cell receptor signaling pathway       6.3E-03    
VEGF signaling pathway       8.4E-03    
T cell receptor signaling pathway       2.1E-02    
Apoptosis       2.1E-02