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Table 6 Genes with somatic mutations regulate both mRNA and miRNA expressions, and formed triangle regulation cycles.

From: Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma

Mutation Gene expression miRNA expression
Gene Gene Damage value P-value for gene expression Up or down regulated miRNA Damage value P-value for miRNA expression Up or down regulated
RB1 LAMP2 0 8.22E-07 Up hsa-mir-340 0 1.16E-06 Down
DST OTUB1 0 5.33E-07 Down hsa-mir-15b 45 1.30E-06 Up
FN1 SSR2 0 3.67E-07 Up hsa-mir-125a 2 4.83E-05 Down
FN1 TDG 3 5.21E-07 Up hsa-mir-125a 2 4.83E-05 Down
TP53 TP53 23 1.40E-07 Up hsa-mir-504 1 1.42E-06 Down
Mutation-gene regression miRNA-gene regression Mutation-miRNA regression
Regression coefficient P-value Coefficient of determination Regression coefficient P-value Coefficient of determination Regression coefficient P-value Coefficient of determination
1.03E+00 7.04E-04 6.47E-02 -2.77E+02 3.17E-06 8.50E-02 1.81E+00 4.10E-09 1.85E-01
1.23E+00 5.91E-04 6.65E-02 -2.28E+01 9.77E-07 9.34E-02 1.27E+00 3.80E-04 7.18E-02
1.54E+00 1.02E-05 1.07E-01 -2.33E+02 4.92E-05 6.52E-02 -1.18E+00 8.72E-04 6.33E-02
1.39E+00 7.60E-05 8.72E-02 -6.91E+01 4.77E-05 6.54E-02 -1.18E+00 8.72E-04 6.33E-02
2.81E-01 3.30E-02 2.62E-02 -4.14E+01 2.72E-06 8.61E-02 3.43E-01 9.10E-03 3.93E-02