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Figure 1 | BMC Systems Biology

Figure 1

From: ExprEssence - Revealing the essence of differential experimental data in the context of an interaction/regulation net-work

Figure 1

Network condensation - exemplified for stimulations. For each of the panels (a) to (d), in the graphs on the left side a stimulator (S) and a target (T) are connected by a stimulation link. Values in the first (E1, upper graph) and second experiment (E2, lower graph) are indicated, where low values are marked green and high values are red (following the heat map metaphor). The coloring scheme is red, pale red, white, pale green and green, in order of decreasing values (see text). The graphs on the right side of each panel show the resulting link after applying our method. For each gene, its values for E1 and E2 are now inlineed simultaneously in the circle (value of E1 on the left, of E2 on the right side). The link connecting both nodes describes the direction and the amount of change between E1 and E2. Links with startup of stimulation are colored in red (a), shutdown links in green (b). If values do not change for both the source and the target, or if they change in a completely inconsistent way, the link is removed, see (c) and (d).

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