Figure 1

Summary of correlations of identified ERα, Pol-II binding peaks with gene expression profile after E2-induced in MCF7 cells. (A) Genes with both ER and Pol-II peak binding in the gene region (between 100 kb upstream of TSS and 100 kb downstream of 3' UTR), 2661 (273 common genes overlapped with gene expression data) for ChIP-seq, 2610 (320 common genes overlapped with gene expression data)for ChIP-PET dataset and 2378 (307 common genes overlapped with gene expression data) for ChIP-chip dataset, respectively. 172(~63%) common genes were found between ChIP-seq and ChIP-PET, this number was higher than the common genes number between ChIP-seq and ChIP-chip (164, ~60%) and common genes number between ChIP-chip and ChIP-PET (183, ~59.6%). (B) The overlapped number of genes of three different technologies.