Peak number, Motif and Regulatory network of MCF7-T cells. (A) Comparison of common genes between MCF7 and MCF7-T cells in ChIP-seq dataset. Genes with both ER and Pol-II peak binding in the gene region (between 100 kb upstream of TSS and 100 kb downstream of 3' UTR), 2661 (273 common genes overlapped with gene expression data) for MCF7 cells, 530 (438 common genes overlapped with gene expression data) for MCF7-T cells, respectively. 58(~21.2%) common genes were found between MCF7 and MCF7-T cells. (B) Transcription factor motifs identified by our de novo ChIPMotifs approach for MCF7-T cells. (C) The Regulatory network for E2 treated MCF7-T cells.