AT1R gene regulatory network model wiring diagram. Nodes represent model species and edges depict chemical reactions. The reaction numbers correspond to those in Additional file 1, Table S1. Kinases have been represented by diamonds, active transcription factors by rounded rectangles, TH mRNA by a hexagon, and the remaining species shown as circles. Total AP-1 is indicated by the box comprising ppc-Fos:ppc-Jun and ppc-Jun:ppc-Jun. Degradation reactions and protein:DNA complexes have been omitted from this diagram. These correspond to reactions 3, 6, 7, 12, 15, 16, 22, 25, 33, 40 and 48. A full description of model reactions can be found in Additional file 1, Tables S1 and S2.