Decision-tree analysis. (A) Decision-tree relating perturbations in model parameters and their hierarchical dependencies to potential Total AP-1 activity responses. (B-D) Specific perturbations leading to (B) ppc-Fos:ppc-Jun alone (C) dynamic balance, and (D) ppc-Jun:ppc-Jun alone. Tree branches represent perturbed parameters, while their edges indicate the magnitude of perturbation. Terminal leaves represent the simulated Total AP-1 activity profile corresponding to ppc-Fos:ppc-Jun alone (left), ppc-Jun:ppc-Jun alone (right), and ppc:Fos:ppc-Jun + ppc-Jun:ppc-Jun (middle).