Number of significant genes and metabolites for any of the investigated perturbations. A. Number of positively or negatively significant metabolites and genes for any of the applied and implied (as explained in Figure 1) perturbations. B. The number of common (positively or negatively) significant metabolites or genes between two perturbations normalized by the product of the number of (positively or negatively, respectively) significant metabolites or genes for each of the perturbations (%).