Figure 2
From: Understanding protein evolutionary rate by integrating gene co-expression with protein interactions
Difference between ePPID and APCC measures. Two hypothetical proteins with the same APCC score ((0.7 × 7 - 0.9 × 3) ÷ 10 = 0.22 for protein A and (0.73 × 3 + 0 × 7) ÷ 10 = 0.22 for protein B) but different numbers of significantly co-expressed interaction partners, thus differing ePPID (see the main text for details) scores (seven versus three). Significantly highly co-expressed interactions are indicated using red, while non-co-expressed and highly anti-co-expressed interactions are indicated using gray and green, respectively.