Figure 5
From: Understanding protein evolutionary rate by integrating gene co-expression with protein interactions
Effects of permanent and transient interfaces on protein evolutionary rate. Mean and standard deviation of protein evolutionary rate dN in the "SIN" dataset are shown for non-co-expressed proteins with single interface (NC-S, in a total of 10 proteins), non-co-expressed proteins with multiple interfaces (NC-M, in a total of 12 proteins), co-expressed proteins with single interface (C-S, in a total of 10 proteins) and co-expressed proteins with multiple interfaces (C-M, in a total of 51 proteins). C-M evolve significantly more slowly than NC-S (P = 1.05e-02), NC-M (P = 1.34e-02) and C-S (P = 2.29e-02). Other comparisons did not yield significant results (i.e., P > 0.05). P is calculated by one-sided Wilcoxon rank sum test.