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Table 1 Spearman correlation of PPID, ePPID and betweenness with protein evolutionary rate.

From: Understanding protein evolutionary rate by integrating gene co-expression with protein interactions

Protein interaction datasets

n

PPID vs. dN

ePPID vs. dN

betweenness vs. dN

  

rho (p)

rho (p)

rho (p)

Y2H-union

1,104

-0.0487(1.06e-01)

-0.142(2.25e-06)

-0.0365(2.26e-01)

Combined-AP/MS

922

-0.158(1.46e-06)

-0.251(1.03e-14)

-0.241(1.21e-13)

LC-multiple

894

-0.172(2.46e-07)

-0.267(4.72e-16)

-0.186(2.05e-08)

Updated-HC

2,245

-0.183(2.62e-18)

-0.242(2.58e-31)

-0.128(1.30e-09)

DIP-CORE

1,342

-0.152(2.33e-08)

-0.254(3.69e-21)

-0.111(4.53e-05)

DIP-FULL

2,572

-0.233(4.56e-33)

-0.271(1.40e-44)

-0.188(5.90e-22)

  1. dN represents protein evolutionary rate measured by non-synonymous substitutions. n is the number of proteins for which both PPID and protein evolutionary rate are available. rho is Spearman rank correlation coefficient, and p is the corresponding statistical significance. Bold indicates that p is significant at the statistical significance level of 0.05.