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Table 2 The variance of protein evolutionary rate explained by PPID and ePPID when controlling for protein abundance.

From: Understanding protein evolutionary rate by integrating gene co-expression with protein interactions

Protein interaction datasets n Percent variance explained in dN
   PPID(p) PPID control for Log(abundance)(p) ePPID (p) ePPID control for Log(abundance) (p)
Y2H-union 793 0.110(3.52e-01) 0.145(2.84e-01) 0.659(2.22e-02) 0.547(3.73e-02)
Combined-AP/MS 763 2.50(1.13e-05) 0.906(8.52e-03) 4.25(9.08e-09) 0.999(5.73e-03)
LC-multiple 680 1.29(3.01e-03) 1.17(4.72e-03) 4.11(9.62e-08) 1.70(6.59e-04)
Updated-HC 1,587 0.722(7.04e-04) 0.547(3.19e-03) 3.53(4.39e-14) 1.32(4.60e-06)
DIP-CORE 968 0.308(8.42e-02) 0.109(3.05e-01) 1.27(4.44e-04) 0.109(3.05e-01)
DIP-FULL 1,792 1.99(2.03e-09) 0.996(2.32e-05) 3.99(1.39e-17) 1.36(7.21e-07)
  1. dN represents protein evolutionary rate measured by non-synonymous substitutions. n is the number of proteins for which PPID, protein evolutionary rate and abundance data are all available. p in column 3 and 5 is the statistical significance of the linear regression of protein evolutionary rate against PPID and ePPID, respectively. p in column 4 and 6 is the statistical significance of the linear regression of protein evolutionary rate against PPID and ePPID when controlling for protein abundance, respectively. Bold indicates that p is significant at the statistical significance level of 0.05.