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Table 4 Principal component regression analysis on six predictor variables and protein evolutionary rate for 752 yeast proteins in the "Y2H-union" dataset.

From: Understanding protein evolutionary rate by integrating gene co-expression with protein interactions

 

Principal Components

 

1

2

3

4

5

6

All

Percent variance explained in dN

34.13***

0.55

0.46

0.38

0.23

0.00

35.74***

Percent contributions

       

mRNA abundance

36.2

1.2

49.1

13.3

0.0

0.2

 

protein abundance

37.3

1.7

50.7

10.2

0.0

0.0

 

gene dispensability

10.4

2.0

0.0

37.2

49.9

0.4

 

gene pleiotropy

11.3

0.0

0.1

38.9

49.2

0.4

 

ePPID

3.9

45.4

0.0

0.3

0.4

49.9

 

betweenness

0.8

49.6

0.1

0.1

0.4

49.0

 
  1. Note: #P < 0.01; *P < 10-3; **P < 10-6; ***P < 10-9. Bold indicates that the predictor variable contributes at least 20% to the corresponding principal component.