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Table 5 Principal component regression analysis on six predictor variables and protein evolutionary rate for 723 yeast proteins in the "Combined-AP/MS" dataset.

From: Understanding protein evolutionary rate by integrating gene co-expression with protein interactions

  Principal Components
  1 2 3 4 5 6 All
Percent variance explained in dN 27.26*** 7.77*** 1.11* 0.92# 0.83# 0.01 37.90***
Percent contributions        
mRNA abundance 24.3 9.0 14.6 47.3 0.3 4.4  
protein abundance 22.8 15.9 13.4 41.3 0.1 6.5  
gene dispensability 8.7 2.5 20.8 1.0 63.2 3.8  
gene pleiotropy 0.0 37.2 40.1 0.0 20.6 2.1  
ePPID 24.5 16.6 4.3 7.5 0.0 47.0  
betweenness 19.7 18.9 6.8 2.8 15.8 36.1  
  1. Note: #P < 0.01; *P < 10-3; **P < 10-6; ***P < 10-9. Bold indicates that the predictor variable contributes at least 20% to the corresponding principal component.