Figure 1

Schematic of the process, tissue, and developmental stage specific genomic data integration pipeline. We used regularized Bayesian classifiers [9] to integrate genome-scale data for A. thaliana including 55 expression datasets from GEO [38] and 5 physical and genetic interaction datasets from BIND [39] and bioGRID [40]. Using curated biological knowledge from the Gene Ontology [14], Plant Ontology[6], and Pfam [15], we reweighted these datasets to infer genome-wide biological networks focused on individual biological processes, developmental stages, and plant tissues.