Figure 2

Performance of the GLOBAL-PROCESS and GLOBAL-DEVEL Networks. The two global networks were evaluated using 5-fold cross-validation with a 20% holdout gene set to test their ability to accurately recover functional and developmental-stage-specific protein interactions. The higher precision of the GLOBAL-DEVEL network suggests that co-functionality during developmental stages can be more accurately inferred from high-throughput data than can more general functional relationships, although both networks are predicted with significant accuracy.