Figure 5

Simulations reproducing previous experimental results. Time courses of [PKMζ] (panels A, C, E, G, I) and EPSC amplitude (panels B, D, F, H, J) are shown. A, B) ZIP administration to a potentiated synapse. C, D) PKMζ perfusion. E, F) Protein synthesis inhibitor administration to a potentiated synapse. G, H) Stimulation in the presence (solid line) or absence (dashed line) of an actin assembly inhibitor. I, J) Reactivation in the presence (solid line) or absence (dashed line) of protein synthesis inhibitor. The dotted line corresponds to protein synthesis inhibition without reactivation. Arrows and bold bars indicate the onset of an LTP-inducing stimulus, Stim(t) = 25 (0 ≤ t < 30), and the duration of drug administration, respectively.