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Figure 2 | BMC Systems Biology

Figure 2

From: Probability distributed time delays: integrating spatial effects into temporal models

Figure 2

Principal simulation scenarios considered in this study. (a) Scenarios (Sc.) 1-3: nuclear translocation of particles A c (Sc. 1), followed by a unary reaction A n B n (Sc. 2) and the translocation reaction competing with the unary reaction A c B c (Sc. 3). (b) Sc. 4-5: nuclear translocation of A c followed by a nuclear binary reaction A n + B n C n (Sc. 4) followed by the cytoplasmic translocation of the product C n (Sc. 5). (c) Sc. 6: upon translocation molecules A n and D n compete for the same binding partner B n (A n + B n C n and D n + B n E n ) (d-e) Sc. 7-8: upon translocation molecules A c are able to dimerize (Sc. 7) or bind to a species initially localized in the cell membrane (Sc. 8). (f) Sc. 9: upon translocation molecules A c dimerize with molecules B c and their product C c is able to translocate back to the nucleus. In all corresponding temporal models of Sc.1-9, each delay distribution accounts for the spatial effects due to the diffusion of particles.

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