Skip to main content
Figure 6 | BMC Systems Biology

Figure 6

From: Probability distributed time delays: integrating spatial effects into temporal models

Figure 6

Comparison of ChemCell and dDSSA trajectories, portraying Scenario 6. Here, delay distributions are obtained from separate ChemCell runs (delay splitting) for each of the two translocation reactions and the competitive binding reactions. Diffusion rates are Dcyt = 10-9 cm2/sec and Dnuc = 10-9 cm2/sec for cytoplasmic and nuclear species, respectively. Cases correspond to different initial conditions: (a) 1000 A c and 1000 D c molecules uniformly distributed in the cytosol; (b-d) 1000 A c and 500 D c molecules (b) uniformly distributed in the cytosol or (c, e) A c is clustered and D c is well mixed, while (d, f) show their corresponding total relative error. All four cases start with 1000 Bn molecules uniformly distributed in the nucleus. In (e, f) we use a modified rate k = 0.015 for A n + B n C n to increase accuracy. To facilitate reading, plots only show nuclear species.

Back to article page