Figure 3

Stochasticity induced at high concentration of a TF. This minimalist system (A1) (see text or table 2 of Additional file 1 for description) that can correspond to simple molecular scenarios (A2) demonstrates that, contrarily to a common idea, increasing the concentration of a TF can result in a larger variability (B). A more precise picture of this phenomenon is provided by observing how distribution changes with TF concentration (C). Robustness of this behavior with respect to deviations from this ideal minimal model are presented in figures S1 and S2 of Additional file 1.