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Table 3 Dual Substrate Assay: Compound IC50 Values (uM)

From: Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro

Compound phospho-MK2 phospho-ATF2 substrate selectivity
SD-0006 0.20 ± 1.1 0.02 ± 1.1 0.09
BIRB 796 3.6 ± 1.4 0.12 ± 1.1 0.03
CMPD1 41 ± 2.2 27 ± 16 0.66
Virtual Cmpd 0.0019 ± 1.1 0.0006 ± 1.2 0.33
  1. IC50's are shown ± standard error. Substrate Selectivity = (ATF2 IC50)/(MK2 IC50)
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BMC Systems Biology

ISSN: 1752-0509

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