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Table 3 Dual Substrate Assay: Compound IC50 Values (uM)

From: Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro

Compound

phospho-MK2

phospho-ATF2

substrate selectivity

SD-0006

0.20 ± 1.1

0.02 ± 1.1

0.09

BIRB 796

3.6 ± 1.4

0.12 ± 1.1

0.03

CMPD1

41 ± 2.2

27 ± 16

0.66

Virtual Cmpd

0.0019 ± 1.1

0.0006 ± 1.2

0.33

  1. IC50's are shown ± standard error. Substrate Selectivity = (ATF2 IC50)/(MK2 IC50)
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BMC Systems Biology

ISSN: 1752-0509

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