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Figure 2 | BMC Systems Biology

Figure 2

From: The internal state of medium spiny neurons varies in response to different input signals

Figure 2

Phosphorylation states of DARPP-32. Differently shaded boxes show singly, doubly and triply phosphorylated states of DARPP-32, and labels indicate phosphorylation positions. Arrows indicate transitions between different phosphorylation forms through enzymatic reactions. Dash-dotted lines with bars represent inhibition. Abbreviations are: protein phosphatase-1 (PP1), protein kinase A (PKAc), dopamine- and cAMP-regulated phosphoprotein with 32 kDa molecular weight (DARPP-32). Different phosphorylation states of DARPP-32 are indicated by the corresponding amino acid(s) and location(s). For instance, (Thr34-Ser102) refers to DARPP-32 phosphorylated simultaneously at positions 34 and 102.

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