Table 2 Reactions and rate constants of signal transduction for DARPP-32 phosphorylation in dendrites of medium spiny neurons in the striatum (see legend of Figure 1 for abbreviations)

D1 + DA ↔ D1_DA

1.1E-3

10.0

[47]

D1_DA + G_αβγ ↔ D1_DA_G_αβγ

6.0E-4

1.0E-3

[47]

D1 + G_αβγ ↔ D1_G_αβγ

6.0E-5

3.0E-4

[47]

D1_G_αβγ+ DA ↔ D1_DA_G_αβγ

3.3E-3

10.0

[47]

D1_DA_G_αβγ → D1_DA + G_αGTP+ G_βγ

20.0^a

[47]

G_αGTP → G_αGDP

10.0^a

[47]

G_αGDP + G_βγ → G_αβγ

100.0

[47]

G_αGTP + AC5 ↔ G_αGTP_AC5

3.9E-2

50.0

[47]

G_αGTP_AC5 + ATP ↔ G_αGTP_AC5_ATP

1.3E-4

2.6E-1

[47]

G_αGTP_AC5_ATP ↔ G_αGTP_AC5 + cAMP

28.5^a

2.6E-4^b

[47]

PKA + 2 cAMP ↔ PKA_cAMP₂

1.3E-5^c

6.0E-3

[47]

PKA_cAMP₂ + 2 cAMP ↔ PKA_cAMP₄

1.7E-5^c

6.0E-2

[47]

PKA_cAMP₄ ↔ 2 PKAc + PKAr

5.1E-4^a

4.8E-3^c

[47]

PDE1 + cAMP ↔ PDE1_cAMP → PDE1 + AMP

2.0E-2

72.0

18.0

[47]

PDE4 + cAMP ↔ PDE4_cAMP → PDE4 + AMP

2.0E-2

72.0

18.0

[47]

PKAc + PDE1 ↔ PKAc_PDE1 → PKAc + PDE1p

6.0E-3

36.0

9.0

[48]

PDE1p → PDE1

1.0E-1^a

[48]

PKAc + PDE4 ↔ PKAc_PDE4 → PKAc + PDE4p

6.0E-3

36.0

9.0

[48]

PDE4p → PDE4

1.0E-1^a

[48]

→ Ca²⁺

2.5E+1^e

[48]

Ca²⁺→

0.6^a/1.7^a

[48]

2 Ca²⁺ + PP2Bi ↔ PP2Bi_Ca₂

1.0E-3^c

1.0

[48]

2 Ca²⁺ + PP2Bi_Ca₂ ↔ PP2B

3.0E-3^c

1.0

[48]

AC5 + Ca²⁺ ↔ AC5_Ca

1.0E-3

0.9

[47]

G_αGTP + AC5_Ca ↔ G_αGTP_AC5_Ca

1.9E-2

25.0

[47]

G_αGTP_AC5_Ca + ATP ↔ G_αGTP_AC5_Ca_ATP

6.0E-5

1.3E-1

[47]

G_αGTP_AC5_Ca_ATP ↔ G_αGTP_AC5_Ca + cAMP

14.2^a

1.3E-4^b

[47]

PP2A + 4 Ca²⁺ ↔ PP2Ac

7.7E-12^d

1.0E-2

[47]

PP2A + PKAc ↔ PP2A_PKAc → PP2Ap + PKAc

2.5E-3

0.3

0.1

[49]

PP2Ap → PP2A

4.0E-3^a

[47]

CK1 → CK1p

1.0^a

[47]

PP2B + CK1p ↔ PP2B_CK1p → PP2B + CK1

3.0E-2

24.0

6.0

[47]

CDK5 + Ca²⁺ ↔ CDK5c

3.0E-3

1.0