TY - JOUR AU - Parkkinen, Juuso A. AU - Kaski, Samuel PY - 2010 DA - 2010/01/25 TI - Searching for functional gene modules with interaction component models JO - BMC Systems Biology SP - 4 VL - 4 IS - 1 AB - Functional gene modules and protein complexes are being sought from combinations of gene expression and protein-protein interaction data with various clustering-type methods. Central features missing from most of these methods are handling of uncertainty in both protein interaction and gene expression measurements, and in particular capability of modeling overlapping clusters. It would make sense to assume that proteins may play different roles in different functional modules, and the roles are evidenced in their interactions. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-4-4 DO - 10.1186/1752-0509-4-4 ID - Parkkinen2010 ER -