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Figure 5 | BMC Systems Biology

Figure 5

From: Searching for functional gene modules with interaction component models

Figure 5

Plate diagrams of the two Interaction Component Models. (A) Plain ICM. Each interaction is assumed to have been generated from a component z, by sampling the end points i and j independently from the multinomial distribution ϕ z . (B) Extension (ICMg2) with gene expression data x i in the nodes; the lower part of the plate is the same as in (A). Node data x i are assumed to have been generated from the same components z as the interactions, by sampling each node i in the data from ϕ z and then its gene expression profile from the normal distribution N (μ z , σ2I). Symbols: multinomial distribution θ over components, component-specific multinomial distributions ϕ z over nodes, distribution hyperparameters α and β, prior and component-specific means μ0 and μ z , prior and shared noise standard deviations σ0 and σ, number of components C, links N and nodes M.

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