Figure 7
From: Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin
Simulated effects of stochastic noise in Blimp-1 gene expression on the LPS dose response curves for (A) percentage of plasma cell formation and (B) averaged accumulated IgM secretion per cell. The dose response curves were obtained from 104 simulated cells under continuous LPS stimulation for 72 h. Blimp-1 noise level was decreased (increased) by simultaneously increasing (decreasing) Blimp-1 transcription rate constant (k13) and decreasing (increasing) Blimp-1 translation rate constant (k15) by the same 5-fold from default values, an alteration that kept the deterministic steady-state level of Blimp-1 protein unchanged. The estimated Hill coefficient and ED50 values are shown in Table 1.