Figure 8
From: Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin
Simulated suppressive effect of TCDD on LPS-stimulated (A) percentage of plasma cell formation and (B) averaged accumulated IgM secretion per cell. The results were obtained from 104 simulated cells under continuous LPS (15 μg/ml) and TCDD treatment for 72 h. The dose response curves with respect to TCDD obtained at 72 h for percentage plasma cells (A, bottom panel) and IgM secretion (B, bottom panel) have an estimated Hill coefficient of 1.12 and 0.98, respectively.