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Table 1 Effects of noise in Blimp-1 protein expression on the steepness and position of the LPS dose response curves.

From: Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin

 

% plasma Cells

IgM Secretion

Blimp-1 noise

nH

ED50

nH

ED50

1.423

1.253

1.074

1.260

1.100

1.928

1.201

0.755

1.188

0.843

3.482

0.959

0.570

1.023

0.650

  1. Note: The quantitative effects of altering Blimp-1 noise level were evaluated for the dose response curves of percentage of plasma cell formation and IgM secretion presented in Figure 7. Blimp-1 noise level is expressed as the coefficient of variation of Blimp-1 protein abundance. The default parameter values of the model generate a coefficient of variation of 1.928. The lower (higher) noise level of 1.423 (3.482) was obtained by increasing (decreasing) Blimp-1 transcription rate constant (k13) and decreasing (increasing) Blimp-1 translation rate constant (k15) by 5-fold, which kept the deterministic steady-state level of Blimp-1 protein unchanged. nH, Hill coefficient; ED50, concentration of LPS (μg/ml) producing 50% of the maximum response.