Note: The quantitative effects of altering Blimp-1 noise level were evaluated for the dose response curves of percentage of plasma cell formation and IgM secretion presented in Figure 7. Blimp-1 noise level is expressed as the coefficient of variation of Blimp-1 protein abundance. The default parameter values of the model generate a coefficient of variation of 1.928. The lower (higher) noise level of 1.423 (3.482) was obtained by increasing (decreasing) Blimp-1 transcription rate constant (k13) and decreasing (increasing) Blimp-1 translation rate constant (k15) by 5-fold, which kept the deterministic steady-state level of Blimp-1 protein unchanged. nH, Hill coefficient; ED50, concentration of LPS (μg/ml) producing 50% of the maximum response.