| % plasma Cells | IgM Secretion |
---|
Blimp-1 noise | nH | ED50 | nH | ED50 |
---|
1.423 | 1.253 | 1.074 | 1.260 | 1.100 |
1.928 | 1.201 | 0.755 | 1.188 | 0.843 |
3.482 | 0.959 | 0.570 | 1.023 | 0.650 |
- Note: The quantitative effects of altering Blimp-1 noise level were evaluated for the dose response curves of percentage of plasma cell formation and IgM secretion presented in Figure 7. Blimp-1 noise level is expressed as the coefficient of variation of Blimp-1 protein abundance. The default parameter values of the model generate a coefficient of variation of 1.928. The lower (higher) noise level of 1.423 (3.482) was obtained by increasing (decreasing) Blimp-1 transcription rate constant (k13) and decreasing (increasing) Blimp-1 translation rate constant (k15) by 5-fold, which kept the deterministic steady-state level of Blimp-1 protein unchanged. nH, Hill coefficient; ED50, concentration of LPS (μg/ml) producing 50% of the maximum response.